硝呋太尔-制霉菌素阴道栓治疗细菌性阴道病的疗效及安全性分析

Efficacy and Safety of Nifuratel-nysfungin Suppository in the Treatment of Bacterial Vaginosis

关键词:  阴道病  细菌性  硝呋太尔-制霉菌素栓  甲硝唑栓

Key words:  vaginosis  bacterial  nifuratel-nysfungin suppository  metronidazole suppository

摘要:

目的 评价硝呋太尔-制霉菌素阴道栓治疗细菌性阴道病的疗效和安全性。方法 本研究采用随机对照试验。试验组80例，对照组78例，分别给予硝呋太尔-制霉菌素栓和甲硝唑栓，疗程分别为6 d和7 d。分别于停药后3~5 d 和停药后月经来潮干净3~7 d观察疗效和安全性。结果 停药后3~5 d，试验组和对照组有效率分别为90.0%和82.5%，差异无统计学意义(P>0.05)，两组间疗效比较无显著差异(P>0.05)；停药后月经来潮干净后3~7 d，试验组和对照组有效率分别为82.5%和73.1%，差异无统计学意义(P>0.05)，两组疗效无显著差异(P>0.05)。试验中未见严重不良反应，不良反应发生率试验组低于对照组(P<0.05)。结论 硝呋太尔-制霉菌素栓治疗细菌性阴道病安全、有效。

Abstract:

OBJECTIVE To evaluate the efficacy and safety of nifuratel-nysfungin suppository in the treatment of bacterial vaginosis. METHODS A randomized and controlled clinical trial was conducted. The 80 patients in trial group were treated with nifuratel-nysfungin suppository and 78 patients in control group were given metronidazole suppository. Six successive days were taken as a course for nifuratel-nysfungin suppository group and seven successive days for metronidazole suppository. The efficacy and safety were observed respectively 3-5 d after treatment and 3-7 d after menorrhea. RESULTS The efficacy rate was 90.0% in trial group and 82.5% in control group on 3-5 d after treatment (P>0.05). There was no significant difference in clinical efficacy between two groups(P>0.05). The efficacy rate was 82.5% in trial group and 73.1% in control group on 3-7 d after menorrhea (P>0.05). There was no significant difference in clinical efficacy between two groups (P>0.05). No severe adverse reactions were found in the trial. The adverse reactions incidence in trial group was lower than that in control group(P<0.5). CONCLUSION Nifuratel-nysfungin suppository is an effective and safe preparation in the treatment of bacterial vaginosis.