| 引用本文: | 王旭;李敬芬;周淑晶;周天明.应用均匀设计研究2-甲基-5-巯基-1,3,4-噻二唑制备工艺[J].中国现代应用药学,1998,(2):31-32. |
| Wang Xu (Wang X) , Li Jingfen (Li JF ) , Zhou Shujing (Zhou SJ) , et al.Investigation of preparation of 2-Methyl-5-Mercapto-1 ,3,4-Thiadiazole with uniform design[J].Chin J Mod Appl Pharm(中国现代应用药学),1998,(2):31-32. |
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| 摘要: |
| 应用均匀设计于标题化合物工艺研究中,以乙酸乙酯和水合肼于二甲苯中反应,加入CS2,直接加热,一步环合成标题化合物,总收率达75.5%。 |
| 关键词: 均匀设计 2-甲基-5-巯基-1,3,4-噻二唑 制备 |
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| Investigation of preparation of 2-Methyl-5-Mercapto-1 ,3,4-Thiadiazole with uniform design |
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Wang Xu (Wang X) , Li Jingfen (Li JF ) , Zhou Shujing (Zhou SJ) , et al
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| Abstract: |
| The uniform design was applied to technological study of the title compound, starting from ethyl acetate and diamine hydrate,followed by reaction with carbon disulfide,the title compound was synthesized in one step.The overall yield amounts to 75.5% . |
| Key words: uniform desing, 2-methyl-5-mercapto-1,3,4-thiadiazole, praparation |
