| 引用本文: | 郭峰;黄光斗;赵枢密;雷晓东1.羧烷基化合成萘普生工艺改进[J].中国现代应用药学,1998,(2):32-33. |
| Guo Feng ( Guo F ) , Huang Guangdou ( Huang GD ), Lei Xiaodong ( Lei XD ), et al.Improved synthesis of dl-naproxen by carboxylation-alkylation[J].Chin J Mod Appl Pharm(中国现代应用药学),1998,(2):32-33. |
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| 摘要: |
| 1-溴-2-甲氧基萘与0-对甲基苯磺酰乳酸乙酯(1)在无水氯化铝催化下经Fniedel-Crafts反应,还原脱溴直接合成dl-萘普生(3),以上反应均在“一锅”内完成,收率达95%(以1-溴-2-甲氧基萘计算)。 |
| 关键词: 萘普生 Friedel-Crafts反应 还原脱溴 |
| DOI： |
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| 基金项目:湖北工学院青年基金项目 |
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| Improved synthesis of dl-naproxen by carboxylation-alkylation |
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Guo Feng ( Guo F ) , Huang Guangdou ( Huang GD ), Lei Xiaodong ( Lei XD ), et al
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| Abstract: |
| dl-Naproxen was directly synthesized via reduction and hydrolysis of ethyl (5-bromo-6-methoxy-2-naphthyl )-a -methyl acetate (2), which was prepared by Friedel-Crafts reaction with 1-bromo-2methoxynaphthalene and ethyl 0-(p-methyl benzene sulfonyl) lactat |
| Key words: dl-naproxen, friedel-crafts reaction, reduction-debromination |
