| 引用本文: | 张士英;吴达俊;孙荣奇1;崔云杰1;靳燕1.1-甲基-3-正丙基吡唑-5-甲酸乙酯的合成(英文)[J].中国现代应用药学,2001,(5):366-367. |
| Zhang Shiying 1(Zhang SY), Wu Dajun (Wu DJ), Sun Rongqi(Sun RQ), Cui Yingjie(Cui YJ), Jin Yan(Jin Y),.Synthesis of 1-methyl-3-n-propylpyrazole 5-carboxylic acid ethyl ester[J].Chin J Mod Appl Pharm(中国现代应用药学),2001,(5):366-367. |
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| 摘要: |
| 目的:合成标题化合物,并进行工艺改进。方法:以2 -戊酮和草酸二乙酯为原料,经三步反应合成了产物。结果:反应的总收率为4 7.7%。合成的各步产品经元素分析、红外和核磁共振光谱确证。结论:改进的工艺具有反应温度低、时间短等优点,并提高了收率。 |
| 关键词: Claisen缩合反应 吡唑 甲基化 |
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| Synthesis of 1-methyl-3-n-propylpyrazole 5-carboxylic acid ethyl ester |
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Zhang Shiying 1(Zhang SY), Wu Dajun (Wu DJ), Sun Rongqi(Sun RQ), Cui Yingjie(Cui YJ), Jin Yan(Jin Y),
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| Abstract: |
| OBJECTIVE:To synthesize the title compound and improve of the process. METHOD:The title compound was synthesized from methyl n propyl ketone and diethyloxalate via three steps. RESULTS:The total yield was 47.7% on the basis of methyl n-proplyl ketone. Th |
| Key words: claisen-condensation, pyrazole, methylation |
