| 引用本文: | 李敬芬;李彬;周淑静;王书红.对氟苄胺合成工艺的改进[J].中国现代应用药学,2001,(5):367-369. |
| LI Jingfen(Li JF), LI Bin(LI B),ZHOU Shujing(ZHOU SJ), WANG Shuhong(Wang SH).Improvement of synthetic process of p-fluorobenzylamine[J].Chin J Mod Appl Pharm(中国现代应用药学),2001,(5):367-369. |
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| 摘要: |
| 目的:获得成本低、工艺简单的合成方法。方法:以对硝基苯甲酸为原料经氟化、酰化和还原3步合成药物中间体对氟苄胺。结果:总收率达3 0 .4 3 %。结论:新的合成方法具有原料易得、成本低廉、操作安全和工艺简单等特点 |
| 关键词: 对氟苄胺 对硝基苯甲酸 合成 |
| DOI： |
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| 基金项目:佳木斯大学校管课题基金的资助 |
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| Improvement of synthetic process of p-fluorobenzylamine |
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LI Jingfen(Li JF), LI Bin(LI B),ZHOU Shujing(ZHOU SJ), WANG Shuhong(Wang SH)
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| Abstract: |
| OBJECTIVE:To simplify the method of synthesizing p-fluorobenzylamine and low the cost of raw material. METHOD:p-Fluorobenzylamine, which is the intermediate compound of some medicine, was synthesized by 3 steps with p-Nitrobenzoic acid as starting materia |
| Key words: p-fluorobenzylamine, p-Nitrobenzoic acid, synthesis |
