| 引用本文: | 王德传;郦邻1;倪佩洲;陆涛.胸腺嘧啶合成工艺的改进[J].中国现代应用药学,2001,(5):369-370. |
| Wang Dechuan(Wang DC), Li Ling(Li L), Ni Peizhou(Ni PZ), Lu Tao(Lu T).A novel method for the synthesis of thymine[J].Chin J Mod Appl Pharm(中国现代应用药学),2001,(5):369-370. |
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| 摘要: |
| 目的:研究合成胸腺嘧啶新的工艺方法。方法:以α-甲基丙烯酸为原料经溴化、成酰氯、与尿素缩合、环合制得胸腺嘧啶。结果:产品收率5 5 % ,熔点与文献相符。结论:相对于以往的工艺,本工艺原料价廉易得、方法操作简便、易于大生产化,是制备胸腺嘧啶的一条很好的途径 |
| 关键词: 胸腺嘧啶 α-甲基丙烯酸 |
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| A novel method for the synthesis of thymine |
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Wang Dechuan(Wang DC), Li Ling(Li L), Ni Peizhou(Ni PZ), Lu Tao(Lu T)
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| Abstract: |
| OBJECTIVE:Study the novel synthetic method of thymine. METHOD: Thymine is prepared by brominating, acylating, condensating with urea and cyclization. RESULTS: The over all yield amounts to 55% and the melting point of product was in accordance with the li |
| Key words: thymine, α-methylcrylic acid |
