| 引用本文: | 谢敏浩;何拥军;罗世能;邹霈;刘娅灵.因卡膦酸二钠的合成[J].中国现代应用药学,2001,(6):456-457. |
| Xie Minhao(Xie MH), He Yongjun(He YJ), Luo Shineng(Luo SN),et al.Synthesis of Incadronate[J].Chin J Mod Appl Pharm(中国现代应用药学),2001,(6):456-457. |
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| 摘要: |
| 目的:合成因卡膦酸二钠,并进行工艺改进。方法:即以环庚胺、亚磷酸二乙酯、原甲酸三乙酸为起始原料,经二步反应合成因卡膦酸二钠。结果:避免了硅胶柱分离工艺,产物经IR、NMR、MS及元素分析、热分析确证了化学结构。结论:合成方法收率稳定,工艺简单 |
| 关键词: 二膦酸盐 因卡膦酸二钠 合成 |
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| Synthesis of Incadronate |
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Xie Minhao(Xie MH), He Yongjun(He YJ), Luo Shineng(Luo SN),et al
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| Abstract: |
| OBJECTIVE: To synthesize Incadronate and optimize the process. METHOD: Taking cycloheptylamine,diethyl phosphite and triethyl orthoformate as the starting material,Incadronate was synthesized by two steps of reaction. RESULTS: Separation of silica gel col |
| Key words: Bisphosphonate, Incadronate, Synthesis |
