| 引用本文: | 徐军;柴雨柱;严相平;叶惠敏;王浦海;冷宗康.芳香酶抑制剂依西美坦(Exemestane)的合成[J].中国现代应用药学,2002,(1):44-46. |
| Xu Jun(Xu J), Chai Yuzhu(Chai YZ), Yan Xiangping(Yan XP), Ye Huimin(Ye HM), Wang Puhai(Wang PH), Leng Zongkang(Leng ZK).Synthesis of aromatase inhibitor exemestane[J].Chin J Mod Appl Pharm(中国现代应用药学),2002,(1):44-46. |
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| 摘要: |
| 目的:合成依西美坦并改进合成工艺。方法:以雄甾烯二酮为原料,经Mannich反应、溴化、脱溴等数步反应制得依西美坦。结果:所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。结论:此路线是可行的 |
| 关键词: 抗癌药 依西美坦 合成 |
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| Synthesis of aromatase inhibitor exemestane |
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Xu Jun(Xu J), Chai Yuzhu(Chai YZ), Yan Xiangping(Yan XP), Ye Huimin(Ye HM), Wang Puhai(Wang PH), Leng Zongkang(Leng ZK)
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| Abstract: |
| OBJECTIVE: To synthesize exemestane and optimize the process. METHOD: This compound was synthesized by steps of Mannich reaction, bromination, and debromination. RESULT: Chemical structure of the product was conformed by element analysis, UV, IR,1HNMR, an |
| Key words: anticancer, exemenstane, synthesis |
