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| 摘要: |
| 目的改进二氢吡啶类钙拮抗剂西尼地平的合成工艺。方法以肉桂醇为原料,经酯化、氨化和缩合-环合而得。结果所得产物结构经红外光谱、核磁共振氢谱及质谱确证,总收率57.3%。结论改进后的合成工艺简单、合理可行。 |
| 关键词: 西尼地平 合成 抗高血压 |
| DOI： |
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| Improved synthesis of cilnidipine |
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GU Zheng-yi,ZHU Yuan
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| Abstract: |
| OBJECTIVE To improve the synthetic procedure of cilnidipine.METHODS Cilnidipine was synthesized from cinnamyl alcohol by esterification,aminization and condensation-cyclization. RESULTS The structure of the product was confirmed by IR,MS and 1H-NMR.The ov |
| Key words: cilnidipine synthesis antihypertensive |
