水蔓菁总黄酮对前列腺炎模型小鼠前列腺及相关组织形态的影响

Effects of Bastard Speedwell Total Flavonoids on Pathomorphology of Prostate and the Correlated Tissues of Prostatitis Model Mice

关键词:  水蔓菁总黄酮  前列腺炎  小鼠模型  病理形态学  前列腺  睾丸  附睾

Key words:  bastard speedwell total flavonoids  prostatitis  model mice  pathomorphology  prostate  testicle  epididymis

摘要:

目的观察水蔓菁总黄酮对前列腺炎模型小鼠前列腺、睾丸及附睾病理形态学改变的影响。方法将60只小鼠随机分为正常对照组、前列腺炎模型组、前列康干预对照组和大、中、小剂量水蔓菁总黄酮干预组；采用前列腺内注入25%消痔灵注射液的方法建立小鼠前列腺炎模型；各种干预药物连续给药21 d后，光镜下观察各组小鼠前列腺、睾丸、附睾的组织形态学改变化。结果模型组小鼠前列腺、睾丸和附睾组织病理改变明显；大、中、小剂量水蔓菁总黄酮干预组小鼠前列腺、睾丸、附睾组织病理改变显著轻于模型组，尤以大、中剂量干预组作用明显。结论水蔓菁总黄酮可显著缓解前列腺炎模型小鼠的前列腺、睾丸、附睾的病理形态学改变。

Abstract:

OBJECTIVE To investigate the effects of bastard speedwell total flavonoids decotion on pathomorphological changes of prostate, testicle and epididymis of prostatitis model mice.METHODS Sixty mice were randomly divided into 6 groups: normal group, prostatitis model group, QIANLIE KANG intervention group and high/middle/low dosage bastard speedwell total flavonoids intervention groups. The mouse prostatitis model was established by injecting 25% hemorrhoid injection into mouse prostate. On 21th day after drug intervention, the changes of prostate, testicle and epididymis histomorphology were observed by light microscope.RESULTS The pathomorphological changes of prostate,testicle and epididymis were slighter in bastard speedwell total flavonoids intervention groups than that of prostatitis model group, especially in the high/middle dosage groups, while the significant pathomorphological changes occurred in prostatitis model group. CONCLUSION Bastard speedwell total flavonoids may significantly relieve pathomorphological changes of prostate and testicle and epididymis.