槟榔碱对细胞增殖、凋亡和炎症反应影响的研究进展

Effects of Arecoline on Proliferation,Apoptosis and Inflammation Response of Cells

关键词:  槟榔碱  细胞增殖  细胞凋亡  炎症反应

Key words:  arecoline  cell proliferation  apoptosis  inflammation response

摘要:

目的与方法综合整理并介绍槟榔碱及其衍生物对细胞增殖和凋亡影响的研究历程及新进展。结果与结论槟榔碱及其衍生物通过产生亚硝胺类和活性氧族的广泛作用，对细胞多个靶点的进攻最终产生系统毒性作用，进一步抑制细胞增殖、阻断细胞周期、诱导细胞的凋亡。通过调节多种具有重要作用的细胞因子的表达，影响机体免疫功能并导致炎症反应的发生。对其结构中的某些基团进行修饰可能导致其生物学效应发生改变，为抗肿瘤新药的开发提供新的思路和途径。

Abstract:

OBJECTIVE and METHODS To review and introduce the research progress of the effect of arecoline and its derivative on cell proliferation and apoptosis.METHODS and CONCLUSION Through the action of nitrosamine and reactive oxygen species,arecoline and its derivative attack multiple target of cell to finally generate systemic toxicity resulting in inhibiting cell proliferation, inducing the cell cycle arrest and cell apoptosis. Arecoline and its derivative could influence the function of immune system with regulating the expression of the important cytokines and resulting in inflammation response. If some groups of arecoline′s structure were modified,its biology action would be changed and the arecoline derivatives were possible to be developed to be the anti-tumour drugs.