丰城鸡血藤对小鼠造血系统损伤保护作用

Protection Effects of Millettia Nitida Benth.var.Hirsutissima Z.Wei on Hematopoietic System of Mice

关键词:  丰城鸡血藤  造血系统  辐射损伤

Key words:  Millettia nitida Benth.var.hirsutissima Z.Wei  hematopoietic system  radiation injury

摘要:

目的 研究丰城鸡血藤对60Co-γ射线照射小鼠造血系统损伤保护作用。方法 连续动态观察不同剂量丰城鸡血藤对小鼠经60Co-γ射线照射后1、7、14、21 d外周血白细胞、红细胞、血红蛋白和血小板的影响，同时比较21 d小鼠脾脏指数、胸腺指数变化。结果 给丰城鸡血藤治疗后小鼠外周血白细胞、红细胞、血红蛋白和血小板计数下降趋势减缓，脾脏指数和胸腺指数高于模型组(P<0.05)。结论 丰城鸡血藤可在一定程度上促进辐射损伤小鼠外周血象的恢复，保护造血系统功能。

Abstract:

OBJECTIVE To explore the protective effects of Millettia nitida Benth.var.hirsutissima Z.Wei on hematopoietics system of sublethal dose 60Coγ-ray irradiated mice. METHODS White blood cell(WBC),red blood cell(RBC), hemoglobin (HGB) and platelet (PLT) counts in peripheral blood of sublethal dose 60Coγ-ray irradiated mice were detected 1,7,14,21 days,the spleen index and thymus index were compared 21 days after intragastion administration of different doses of Millettia nitida Benth.var.hirsutissima Z.Wei,successively. RESULTS A slowdown of the decrease of WBC,RBC,HGB and PLT counts in peripheral blood of the irradiated mice was observed after intragastric administration of Millettia nitida Benth.var.hirsutissima Z.Wei,spleen index and thymus index were higher than those of the model control group(P<0.05. CONCLUSION Millettia nitida Benth.var.hirsutissima Z.Wei can accelerate the recovery of WBC,RBC,HGB and PLT counts in peripheral blood and protect the hematopoietic system of the irradiated mice.