木通提取物对实验性大鼠静脉血栓形成的影响

The Influence of Akebiae Extract on the Formation of Venous Thrombosis in Rats

关键词:  木通提取物  大鼠  静脉血栓

Key words:  akebiae extract  rats  venous thrombosis

摘要:

目的 探讨活血化瘀中药木通的提取物对大鼠实验性静脉血栓形成的影响，为木通提取物治疗静脉血栓提供实验依据。方法 利用大鼠静脉血栓形成模型测定给予木通提取物100，200 mg·kg-1后血栓湿重和干重，另有模型组(给予0.9%氯化钠溶液)和阳性对照组(华法林)进行对比，分别计算其各血栓形成抑制率。结果 木通提取物100 mg·kg-1组对大鼠静脉血栓形成有一定影响，木通提取物200 mg·kg-1组可以明显抑制大鼠静脉血栓形成，减轻血栓湿重和干重，对血栓湿重抑制率分别为19.9%和48.6%，对血栓干重抑制率分别为15.5%和42.8%。 结论 木通提取物可抑制大鼠实验性静脉血栓形成。

Abstract:

OBJECTIVE To study the influence of akebiae extract on the formation of venous thrombosis in rats and offer experiment basis to cure venous thrombosis. METHODS Copy the rat model of venous thrombosis associated with oral administration of akebiae extract(100, 200 mg·kg-1). At the same time, there are two other groups: model group(given 0.9% NaCl), positive contrast group(given warfarin sodium). At the end of the experiment, the thrombus wet weight and thrombus dry weight of the rats were measured and the inhibitory rates in the formation of venous thrombosis were calculated. RESULTS Compared with the model group, the thrombus wet weight and dry weight of rats given 100 mg·kg-1 of akebiae extract showed only a trend of reduction, while 200 mg·kg-1 of akebiae extract had the remarkable effect of resisting the thrombus formation. And the inhibitory rates of wet weight were 19.9% and 48.6% , the inhibitory rates of dry weight were 15.5% and 42.8%, respectively. CONCLUTION Akebiae extract could significantly inhibit the formation of venous thrombosis in rats.