丹酚酸B静脉注射对麻醉犬血流动力学的影响

Effects of Salvianolic Acid B Injection on Hemodynamic Ariables in Anaesthetized Open-chest Dogs in Vivo

关键词:  心肌缺血  犬  血流动力学  丹酚酸B  静脉注射

Key words:  coronary disease  cardiac muscle ischemia  dogs  hemodynamics  salvianolic acid B  intravenous injection

摘要:

目的 观察注射用丹酚酸B对麻醉犬血流动力学的作用。方法 分别以0.8,1.6,3.2.0 mg·kg-1原料(低、中、高剂量)静脉注射给予麻醉开胸犬,观察给药后血压与心率、心输出量与冠脉流量(CBF)、左室内压等血流动力学指标的变化。结果 丹酚酸B 3.2 mg·kg-1组对舒张压(DAP) 、平均动脉压(MAP)有降压作用,对心率(HR)有减慢趋势,在给药后30 min内与对照组比较差异显著; 丹酚酸B高剂量组能明显增加CBF，在给药后15 min内与对照组比较差异显著；丹酚酸B高剂量组能明显降低左心室舒张末期压力(LVEDP)，在给药后15 min内与对照组比较差异显著。结论 丹酚酸B注射途径给药能改善麻醉犬血流动力学，调节心脏的功能,具有一定的临床治疗作用。

Abstract:

OBJECTIVE To investigate hemodynamic ariables in anaesthetized open-chest dogs after the intravenous injection of salvianolic acid B. METHODS The hemodynamic ariables of open-chest dogs were observed after intravenous injection of salvianolic acid B (SAL-B) at doses of 0.8, 1.6, 3.2 mg·kg-1. RESULTS 3.2 mg·kg-1 SAL-B had the potency of decreasing the DAP, MAP, and HR of the experimental dogs in first 30 minutes, 3.2 mg·kg-1 of SAL-B significantly increased CBF and decreased LVEDP of the experimental dogs. And these test results in experimental group were significantly different from those in control group at some time points. CONCLUSIONS SAL-B has effect of improving cardiac function, which indicates SAL-B has a well perspective of clinical value.