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| 摘要: |
| 目的评价自制黄杨宁缓释胶囊在犬体内的药动学。方法Beagle犬分别单剂量口服给药6 mg自制黄杨宁缓释胶囊和市售黄杨宁普通片，两次交叉试验间隔两周。采用反相高效液相色谱法，测定犬给药后不同时间的血药浓度，用以估算药动学参数和相对生物利用度。结果黄杨宁缓释胶囊和黄杨宁普通片的Cmax分别为(5.28±0.81) ng·mL-1和(11.70±2.01) ng·mL-1，tmax分别为(4.3±0.5) h和(1.0±0.1) h。缓释胶囊相对于普通片的生物利用度为96.23%。结论黄杨宁缓释胶囊具有显著的缓释效果。 |
| 关键词: 黄杨宁 缓释胶囊 药动学 相对生物利用度 |
| DOI： |
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| Pharmacokinetic Study of Huangyangning Sustained-Release Capsules in Dogs |
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WANG Ruwei1，YAO Dandan2，ZHANG Xiaoping2，YE Jianfeng
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| Abstract: |
| OBJECTIVE To investigate the pharmacokinetic of Huangyangning sustained-release capsules in dogs. METHODS Two groups of Beagle dogs were dosed with 6 mg Huangyangning sustained-release capsules or Huangyangning tablets via orally administration, and two groups were treated alternatively after two weeks. The blood drug concentrations were determined by HPLC to estimate the pharmacokinetic parameters and the relative bioavailability. RESULTS The Cmax values of Huangyangning sustained-release capsules and Huangyangning tablets were (5.28±0.81) ng·mL-1 and (11.70±2.01)ng·mL-1, the tmax values were (4.3±0.5) h and (1.0±0.1) h, respectively. The relative bioavailability of sustained-release capsules was 96.23%. CONCLUSION Huangyangning sustained-release capsules have significantly characteristic of sustained-release. |
| Key words: Huangyangning sustained-release capsules pharmacokinetics relative bioavailability |
