注射用舒血宁抗心肌缺血作用评价

Protective Effects of Shu Xue Ning Inject Liquid on Myocardial Ischemia

关键词:  注射用舒血宁  心肌缺血

Key words:  Shu Xue Ning inject liquid  myocardial ischemia

摘要:

目的 研究注射用舒血宁对心肌缺血的保护作用。方法 观察注射用舒血宁对异丙肾上腺素和垂体后叶素致大鼠心肌缺血、冠状动脉结扎引起的家犬心肌缺血等动物心肌缺血模型的作用和对离体大鼠心脏灌流量的影响。结果 注射用舒血宁能明显抑制异丙肾上腺素和垂体后叶素诱导的大鼠心肌缺血，使冠脉结扎引起的家犬心肌缺血范围明显减少，心外膜电位显示缺血程度降低，增加离体大鼠心脏冠脉流量。结论 注射用舒血宁能明显扩张血管、增加冠状动脉流量，抑制冠状动脉结扎引起的心肌缺血范围和缺血程度。

Abstract:

OBJECTIVE To investigate the protective effects of Shu Xue Ning inject liquid on myocardial ischemia. METHODS The protective effect of Shu Xue Ning inject liquid on myocardial ischemia was investigated in myocardial ischemia rats induced by isoproterenol and hypophysin, myocardial ischemia dogs caused by coronary artery ligation and perfusion of isolated rat hearts. RESULTS Shu Xue Ning inject liquid significantly inhibited myocardial ischemia of rats induced by isoproterenol and hypophysin, significantly decreased the range of canis familiaris myocardial ischemia caused by coronary artery ligation, the electrical potential of epicardium revealed that the extend of ischemic decreased, increased the flow of aeteria coronaria. CONCLUSION These results show that Shu Xue Ning inject liquid can significantly dilate the blood vessels, increase the flow of aeteria coronaria, inhibit the range and the degree of myocardial ischemia induced by coronary artery ligation.