| 引用本文: | 吴军，谢敏浩，刘娅灵，邹霈，何拥军，王洪勇.L-5-(2-乙酰氧基-丙酰胺基)-2,4,6-三碘异酞酰氯的合成[J].中国现代应用药学,2009,(13):1134-1135. |
| WU Jun，XIE Minhao，LIU Yaling，ZOU Pei，HE Yongjun，WANG Hongyong.Synthesis of L-5-(2-acetoxy-propionylamino)-2,4,6-triiodoisophthaloyl dichloride[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(13):1134-1135. |
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| 摘要: |
| 目的合成标题化合物，并进行改进。方法以5-氨基-2,4,6-三碘异酞酸为原料经酰氯化、酰胺化反应制得目标化合物。结果总收率达95.4%，目标化合物的结构经红外光谱和元素分析确证。结论改进的路线操作简便，易于控制，缩短了反应时间，降低了生产成本，更易于工业化生产。 |
| 关键词: 碘帕醇 中间体 合成 |
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| Synthesis of L-5-(2-acetoxy-propionylamino)-2,4,6-triiodoisophthaloyl dichloride |
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WU Jun，XIE Minhao，LIU Yaling，ZOU Pei，HE Yongjun，WANG Hongyong
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| Abstract: |
| OBJECTIVE To synthesize the title compound and improve the process.METHODS The title compound was synthesized from 5-amino-2,4,-6-triiodoisophthalic acid by acyl chlorination and amidation.RESULTS The overall yield was 95.4%,the title compound was characterized by IR and elemental analysis.CONCLUSION This synthetic technique is simple,economical and suitable for industrial manufacture. |
| Key words: iopamidol intermediate synthesis |
