| 引用本文: | 贺新,邱岳进.3,4,5-三甲氧基苯乙酸合成工艺改进[J].中国现代应用药学,2010,27(1):32-34. |
| .Improvement of Synthesis Process for 3,4,5-Trimethoxyphenyl Acetic Acid[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(1):32-34. |
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| 摘要: |
| 目的 合成3,4,5-三甲氧基苯乙酸并进行工艺改进。方法 以3,4,5-三甲氧基苯甲醛为起始原料，经硼氢化钾还原、氯化、氰化、水解“一锅”反应得到3,4,5-三甲氧基苯乙酸。结果 所得产物经核磁共振谱确证，总收率64.2%。结论 改进后的工艺，操作简便，环境污染小，更适合工业化生产。 |
| 关键词: 3,4,5-三甲氧基苯乙酸 米库氯铵 一锅法合成 |
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| Improvement of Synthesis Process for 3,4,5-Trimethoxyphenyl Acetic Acid |
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HE Xin1 QIU Yuejin2
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| Abstract: |
| OBJECTIVE To improve the synthesis process of 3,4,5-trimethoxyphenyl acetic acid. METHODS 3,4,5-methoxyphenyl acetic acid was synthesized from 3,4,5-trimethoxybenzaldehyde by reduction with KBH4 in water, followed by chlorination, cyanation and hydrolysis in one-pot. RESULTS The overall yield was 64.2%. The structure of 3,4,5-trimethoxyphenyl acetic acid was confirmed by 1H-NMR. CONCLUSION The synthetic process is practical and easy to be scaled up. |
| Key words: 3,4,5-trimethoxyphenyl acetic acid mivacurium chloride one-pot synthesis |
