醒脑再造胶囊对大鼠血瘀性脑缺血模型血液流变学的影响

Effects of Xingnaozaizao Capsule on the Hemorheology of Blood Stasis and the Cerebral Ischemia Rat Models

关键词:  醒脑再造胶囊  脑缺血  血液流变学

Key words:  Xingnaozaizao capsules  cerebral ischemia  hemorheology

摘要:

目的 探讨醒脑再造胶囊对血瘀性脑缺血大鼠模型血液流变学的影响。方法 采用肌内注射地塞米松造血瘀模型,双侧颈总动脉结扎造脑缺血模型。将血瘀模型大鼠分为6组，分别灌服大、中、小剂量的醒脑再造胶囊混悬液、中风回春片混悬液和同体积生理盐水(2组)，另设一组空白对照组，每天给药1次，连续给药11 d。实验结束时，动物麻醉后分离两侧颈总动脉作结扎术，完全空白组和其中一组生理盐水组施假手术。断头取血，肝素抗凝，测全血黏度、血浆黏度、红细胞刚性、红细胞聚集指数等。结果 与模型组比较，大、中、小剂量醒脑再造胶囊组和中风回春片组均可显著降低全血黏度，显著降低全血低切还原黏度和全血低切黏度；中剂量醒脑再造胶囊组可使模型大鼠血浆黏度明显降低；醒脑再造胶囊组可显著降低全血高切还原黏度、全血高切黏度、红细胞刚性和红细胞聚集指数。结论 醒脑再造胶囊可显著改善大鼠血瘀性脑缺血模型血液流变学指标。

Abstract:

OBJECTIVE To explore the effects of Xingnaozaizao capsules on the hemorheology of blood stasis and the cerebral ischemia rat models. METHODS The blood stasis rat models were induced by intramuscular injection of the dexamethasone, and the cerebral ischemia rat models were induced by bilateral common carotid artery ligation. The blood stasis model rats were divided into six groups, rats were fed with large, medium and small-dose Xingnaozaizao capsule suspension, Zhongfenghuichun tablet suspension and the same volume of saline (two groups), and the other set up a group of blank control group, administered one time per day, continuous administration for 11 d. At the end of the experiment, the two common carotid arteries were applied by ligation after anesthesia animals separated, completely blank group and one group of saline group were implemented by the sham-operated. And then, decapitated blood, heparin anticoagulation, measured whole blood viscosity, plasma viscosity, erythrocyte rigidity, erythrocyte aggregation index. RESULTS Compared with model group, large, medium and small-dose Xingnaozaizao capsule and Zhongfenghuichun group could significantly reduce WBV, significantly reduce low-shear whole blood viscosity reduction and low-shear whole blood viscosity. Middle dose Xingnaozaizao capsule can obviously decrease plasma viscosity. Xingnaozaizao capsule can significantly (obviously) reduce high-shear whole blood reduction viscosity, high shear whole blood viscosity, erythrocyte rigidity and erythrocyte aggregation index. CONCLUSION Xingnaozaizao capsule could significantly improve the hemorheology of the blood stasis and cerebral ischemia rat models.