阿米福汀滴注速度与恶心呕吐的相关性分析

Amifostine Infusion Rate and the Correlation of Malignant Vomiting

关键词:  阿米福汀  滴注速度  恶心呕吐  骨髓保护

Key words:  amifostine  drip rate  nausea  protection of bone marrow

摘要:

目的 研究阿米福汀滴注速度的快慢与恶心呕吐分级和骨髓保护作用的相关性。方法 采用随机的分组方法将35例化疗患者分为A组17例和B组18例，均接受相同周期的化疗。2组I周期(对照组)，化疗前用阿米福汀时间严格控制在15 min内；II周期(实验组)，化疗前用阿米福汀时间控制在60 min内。2个周期后评价恶心呕吐分级和血液毒性。结果 A组和B组患者在I周期(对照组)出现恶心呕吐的人次、程度均明显高于II周期(实验组)(P<0.01)；而A组和B组患者在I周期和II周期化疗后的外周血毒性无显著性差异(P>0.05)。结论 阿米福汀滴注速度的快慢，对骨髓保护作用无明显差异，但适当延长阿米福汀使用时间，可以明显减少恶心呕吐的发生率。

Abstract:

OBJECTIVE To study the correlation between the drip rate of amifostine and the degree of nausea, the protection of bone marrow. METHODS There were 35 patients who were divided into group A and group B randomly, all of them received two periods of chemotherapies. In period I (control period), the patients were administrated with amifostine in 15 minutes before chemotherapeutics, however, the time was regulated in 60 minutes in prerion II(experimental period). The degree of nausea and toxicity of bone marrow were estimated after two periods. RESULTS Incidence rate of nausea in period I highly exceeded than period II for patients both in group A and B (P<0.01), but there was no obvious difference of the toxicity of bone marrow for patients between group A and B in period I and II. CONCLUSION There is no evidence showed that drip rate of amifostine was correlated to protection of bone marrow, whatever, to prolong the time of amifostine is thought to reduce the incidence rate of nausea.