亲水性蛋白和多肽固体脂质纳米粒的制备方法

Preparation Methods of Solid Lipid Nanoparticles for Hydrophilic Peptides and Proteins

关键词:  固体脂质纳米粒  制备方法  亲水性蛋白

Key words:  solid lipid nanoparticles(SLN)  preparation methods  hydrophilic proteins

摘要:

目的 近年来，随着生物技术和基因工程的进步，许多新的具有药用活性的蛋白和多肽得到了发展。然而，由于蛋白和多肽的亲水性和不稳定性，需要选择特殊的载体和制备工艺，以克服药物本身的缺陷。方法 本综述描述了在优化的制备方法下，固体脂质纳米粒(SLN)作为亲水性的蛋白和多肽药物的可选择载体，用来包封亲水性蛋白和多肽。结果 SLN作为载体可以改善蛋白的稳定性，避免其水解，并能够实现药物分子的持续释放。结论 因此，许多重要的多肽和蛋白已被包封进SLN或正在研究当中。

Abstract:

OBJECTIVE In recent years, many new pharmaceutically active proteins and peptides have been developed due to the progress of biotechnological techniques and genetic engineering. However, many of them require special formulation technologies to overcome drug-associated problems such as hydrophilic and instability. METHODS This review described that solid nanoparticles (SLN) have been sought as an alternative carrier for hydrophilic proteins and peptides under optimized preparation methods to incorporate the drug. RESULTS Formulation in SLN confers improved proteins stability, avoids proteolytic degradation, as well as sustained release of the incorporated molecules. CONCLUSION Thus, many important peptides and proteins have been incorporated into SLN and are currently under investigation.