比索洛尔对老年永久性心房颤动并慢性心功能不全患者心肌能量代谢变化的影响

Effect of Bisoprolol on Myocardial Energy Expenditure(MEE) in Older Patients with Heart Failure(HF) and Chronic Fibrillation Atrial

关键词:  慢性房颤  心衰  超声心动图  比索洛尔  心肌能量消耗

Key words:  atrial fibrillation  heart failure  echocardiography  bisoprolol  myocardial energy expenditure

摘要:

目的 观察比索洛尔对老年永久性心房颤动并慢性心功能不全患者心肌能量代谢的影响。方法 48例老年永久性心房颤动并慢性心功能不全患者随机分成2组，分别给予比索洛尔(实验组)和地高辛(对照组)治疗12个月，治疗前后采用多普勒超声心动图检测并计算心肌能量消耗(MEE)及常规结构指标，左心室收缩(LEVF、LVFS)舒张(IVRT、EDT)及整体功能指标(Tei指标)。结果 2组治疗前后，左心房内径(LA)无明显变化，与治疗前相比无统计学意义(P>0.05)；2组患者治疗后心功能均有改善，有统计学意义(P<0.01)；实验组与对照组相比，在RWT、LVMI、LVM、Tei指数、cESS、MEE/sys、MEE/min、NT-proBNP 等指标变化明显，具有统计学意义(P<0.01)。结论 比索洛尔可改善老年永久性房颤患者左心室重构和心功能，可以明显降低心肌的能量消耗。

Abstract:

OBJECTIVE To observe the effect of bisoprolol on myocardial energy expenditure (MEE) in older patients with heart failure (HF) and chronic fibrillation atrial. METHODS Forty-eight patients with atrial fibrillation were randomly divided into two groups: the observations were added with bisoprolol and the others were added with digoxin. The whole case were lasted for 12 months. To evaluate the relationship between MEE, LEVF、LVFS, Tei with patients. RESULTS LA of patients were not changed in 2 groups before and after treatment (P>0.05). To impove on heart function in 2 groups after treatment. RWT, LVMI, LVM, Tei index, cESS, MEE/sys, MEE/min, NT-proBNP were significantly higher in controls (P<0.01). CONCLUSION Bisoprolol can improve the left ventricle structural remodeling and heart function and reduce myocardial energy expenditure.