| 引用本文: | 陈韩英,陈韩飞,李德芳,张波,王振华,郑秋生.新疆软紫草多糖体内抗肿瘤作用研究[J].中国现代应用药学,2010,27(12):1061-1064. |
| .Effect of Arnebia euchroma (Royle) Johnst Polysaccharide on Mice Bearing in U14 Cervical Cancer in Vivo[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(12):1061-1064. |
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| 摘要: |
| 目的 研究新疆软紫草多糖对小鼠宫颈癌U14生长的抑制作用。方法 建立小鼠宫颈癌U14实体瘤与腹水瘤两种模型，观察软紫草多糖对实体瘤抑瘤率、胸腺和脾脏免疫器官重量和腹水瘤生命延长率的影响。结果 软紫草多糖3个剂量组对U14实体瘤小鼠均具有明显的抑制作用(P<0.05)，对U14腹水瘤小鼠具有明显的延长存活期作用(P<0.05)，中剂量组能明显增加U14实体瘤小鼠的脾指数，高、中剂量组能明显降低胸腺指数。结论 软紫草多糖对小鼠宫颈癌U14的生长有一定的抑制作用。 |
| 关键词: 软紫草多糖 U14 体内抑瘤 |
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| Effect of Arnebia euchroma (Royle) Johnst Polysaccharide on Mice Bearing in U14 Cervical Cancer in Vivo |
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CHEN Hanying1 2 CHEN Hanfei3 LI Defang1 ZHANG Bo1 2 WANG Zhenhua1 2 ZHENG Qiusheng1 2*
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| Abstract: |
| OBJECTIVE To investigate the effect of crude polysaccharides from Arnebia euchroma (Royle) Johnst(ARPS) anti-tumor of mice bearing uterine cervical carcinoma (U14) in vivo. METHODS The effect of ARPS on the inhibition rate of solid tumor, thymus index, spleen index and the life span of ascites tumor were conducted with the experiment model in vivo of animal tumor. RESULTS ARPS had obvious anti-tumor effects to U14-mice (P<0.05), could prolong U14-mice life, and medium dose group increased effect on spleen index (P<0.05), high and medium dose groups decreased effects on thymus index (P<0.05). CONCLUSION The result indicated that ARPS could inhibited the development of U14 cervical cancer in mice. |
| Key words: Arnebia euchroma (Royle) Johnst polysaccharide U14 tumor inhibition in vivo |
