基于肠心轴学说探讨肠道菌群在心血管疾病中的作用

Investigate the Role of Intestinal Flora in Cardiovascular Diseases Based on the Intestinal Axis Theory

关键词:  肠心轴  肠道菌群  心血管疾病  代谢物

Key words:  intestinal axis  intestinal flora  cardiovascular disease  metabolites

摘要:

肠道内庞大的菌群之间相互依存、相互制约，协同参与机体生理代谢和营养物质的消化。肠道菌群与心血管健康相关研究已成为十分重要的研究领域，肠道菌群组成的改变、肠道菌群产生的代谢产物和毒素都能引发心血管系统的病变。心血管疾病（cardiovascular disease，CVD）因高发病率和死亡率已成为一个主要的健康问题，CVD的发生、发展中肠道特定菌群的改变已被确定为疾病发生的关键因素。然而，肠道菌群及其代谢产物如何产生及影响CVD的潜在机制仍不清楚。本文就肠道菌群通过肠心轴调节CVD的最新研究进展进行综述，重点总结肠道微生物及其代谢产物与CVD发生发展之间复杂的相互作用，以及肠道菌群失调的改变对心血管事件发生的影响，探讨肠道菌群与CVD发病机制之间的因果联系。

Abstract:

The large intestinal flora is interdependent and mutually restricted, and synergistically participates in the physiological metabolism of the body and the digestion of nutrients. The study on intestinal flora and cardiovascular health has become a very important research field. Changes in intestinal flora composition, metabolites and toxins produced by intestinal flora can cause cardiovascular system lesions. Cardiovascular disease(CVD) has become a major health problem due to high morbidity and mortality. The changes in specific intestinal flora have been identified as the key factors in the occurrence and development of CVD. However, the underlying mechanism of how intestinal flora and metabolites produce and affect CVD remains unclear. In this paper, the latest research progress of intestinal flora in regulating CVD through the intestinal cardiac axis are reviewed, focusing on the complex interaction between intestinal microorganisms and their metabolites and the occurrence and development of CVD, as well as the effect of changes in intestinal flora imbalance on the occurrence of cardiovascular events, to discuss a causal link between intestinal flora and the pathogenesis of CVD.