| 引用本文: | 罗细林,覃丽,李昕,徐兵,邓阳,童焕.利福平致肝损伤的毒理机制及中药配伍减毒研究进展[J].中国现代应用药学,2021,38(9):1125-1132. |
| LUO Xilin,QIN Li,LI Xin,XU Bin,DENG Yang,TONG Huan.Research Progress in Toxicological Mechanisms of Rifampicin-induced Liver Injury and Detoxification Mechanisms of Chinese Herbal Medicine[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(9):1125-1132. |
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| 利福平致肝损伤的毒理机制及中药配伍减毒研究进展 |
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罗细林1,2,3, 覃丽3, 李昕1,2, 徐兵1,2, 邓阳1,2, 童焕1,2
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1.长沙市第三医院药学部, 长沙 410015;2.长沙市抗菌药物临床应用研究所, 长沙 410015;3.湖南中医药大学药学院, 长沙 410208
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| 摘要: |
| 利福平（rifampicin，RFP）作为一线抗结核药物，主要经肝脏代谢，在抗结核治疗过程中常见肝损伤不良反应。目前多种中药显示明确的减毒作用，但作用机制均未明确。本文从代谢紊乱、氧化应激、炎症、细胞凋亡等方面对RFP引起肝损伤的毒理机制进行探讨，并综述了RFP与中药配伍减毒的肝损伤防治研究进展，以期为临床防治以及相关基础研究的开展提供参考。 |
| 关键词: 利福平 肝损伤 中药 减毒 氧化应激 细胞凋亡 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.09.020 |
| 分类号:R969 |
| 基金项目:湖南省自然科学基金青年基金项目（2019JJ50680）；湖南省科技计划项目（2016SK4008）；湖南省医学会医学科研基金临床药学项目（HMA202001009）；长沙市科技计划项目（kq1801123） |
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| Research Progress in Toxicological Mechanisms of Rifampicin-induced Liver Injury and Detoxification Mechanisms of Chinese Herbal Medicine |
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LUO Xilin1,2,3, QIN Li3, LI Xin1,2, XU Bin1,2, DENG Yang1,2, TONG Huan1,2
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1.Department of Pharmacy, The Third Hospital of Changsha, Changsha 410015, China;2.The Clinical Application Research Institute of Antibiotics in Changsha, Changsha 410015, China;3.School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
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| Abstract: |
| Rifampicin(RFP) acts as a front-line anti-tuberculosis drug, which is mainly metabolized by the liver, with liver injury as common adverse reactions during anti-tuberculosis treatment. At present, a variety of traditional Chinese medicine shows a clear poison reduction effect, but the mechanism of action is not clear. This paper explores the toxicological mechanism of RFP liver injury from the aspects of metabolic disorder, oxidative stress, inflammation and apoptosis, and reviews the research progress of liver injury prevention and treatment with RFP combined with traditional Chinese medicine in order to provide reference for clinical prevention and treatment and related basic research. |
| Key words: rifampicin liver injury Chinese herbal medicine detoxification oxidative stress apoptosis |
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