黑皮质素受体4激动剂的研究进展

赵宏丽; 冯贵龙<sup>*</sup>

引用本文:	赵宏丽,冯贵龙.黑皮质素受体4激动剂的研究进展[J].中国现代应用药学,2021,38(13):1634-1638.
	ZHAO Hongli,FENG Guilong.Research Progress of Melanocortin-4 Receptor Agonist[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(13):1634-1638.

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黑皮质素受体4激动剂的研究进展
赵宏丽^1,2, 冯贵龙²
1.山西医科大学, 太原 030001;2.山西医科大学第一医院急诊科, 太原 030001

摘要:

黑皮质素受体4（melanocortin-4 receptor，MC4R）是一种参与中枢调节的G蛋白偶联受体，主要存在于皮质、丘脑、下丘脑、脑干。激活MC4R可产生多种生理功能，因此本文就近年来新发现的外源性MC4R激动剂RM-493、RO27-3225和PT-141的生理功能及其研究进展做一综述，旨在为今后临床用药提供参考。

关键词: 黑皮质素受体4 RM-493 RO27-3225 PT-141

DOI：10.13748/j.cnki.issn1007-7693.2021.13.016

分类号:R961

基金项目:国家临床重点专科建设项目（国卫办医函[2013]544号）

Research Progress of Melanocortin-4 Receptor Agonist

ZHAO Hongli^1,2, FENG Guilong²

1.Shanxi Medical University, Taiyuan 030001, China;2.Department of Emergency, First Hospital of Shanxi Medical University, Taiyuan 030001, China

Abstract:

Melanocortin-4 receptor(MC4R) is a G-protein-coupled receptor involved in central regulation, which mainly exists in cortex, thalamus, hypothalamus and brain stem. Activation of MC4R can produce a variety of physiological functions, so the recent discovery of exogenous MC4R agonists RM-493, RO27-3225 and PT-141 as well as their physiological functions and research progress are reviewed in this paper to reference evidence for future clinical use.

Key words: melanocortin-4 receptor RM-493 RO27-3225 PT-141