艾迪注射液治疗15例高凝状态结直肠癌的临床观察

Clinical Observation on 15 Colorectal Cancer Patients in Blood Hypercolktive State Treated with Aidi Injection

关键词:  D-二聚体  结直肠癌  艾迪注射液  高凝状态

Key words:  D-dimer  colorectal cancer  Aidi injection  blood hypercolktive state

摘要:

目的 观察艾迪注射液对血浆D-二聚体的干预作用，探讨其对结直肠癌患者高凝状态的影响。 方法 筛选30例D-二聚体异常升高的具有复发高危因素Dukes’B期以上的结直肠癌患者，随机分为对照组与治疗组，每组15例，均采用标准FOLFOX或XELOX方案化疗，治疗组联合使用艾迪注射液，在疗程前后用免疫比浊法测定血浆D-二聚体值。结果 对照组D-二聚体升高10例，降低5例，均值在治疗前后统计学无差异；治疗组D-二聚体升高3例，降低12例，均值在治疗前后差异有统计学意义(P<0.01)，并且2组D-二聚体降低率的差异具有统计学意义(P<0.05)，二者治疗前后D-二聚体的净效应之间差异有统计学意义(P<0.01)。结论 艾迪注射液可降低高凝状态结直肠癌患者的D-二聚体水平，化疗对结直肠癌患者的D-二聚体水平无显著影响。

Abstract:

OBJECTIVE To explore the intervention effect of Aidi injection on blood hypercolktive state of 15 patients with advanced colorectal cancer by means of testing plasma D-dimer’s levels. METHODS Thirty cases with colorectal cancer with abnormal D-dimer values were randomly divided into control group and treatment group, 15 cases in each group, and treated with chemotherapy or Aidi injection combining chemotherapy separately. Their plasma D-dimer concentrations were measured by immunoturbidimetric assay before and after treatment. RESULTS D-dimer concentrations of 10 cases in control group rose, the others reduced. No significant difference was found before and after treatment. D-dimer concentrations of 3 cases in treatment group rose, the others reduced. A significant difference of mean was found before and after treatment(P<0.01). The rate of decline and the deviation values of D-dimer were statistically significant difference between two groups(P<0.05 and P<0.01). CONCLUSION Aidi injection can ameliorate D-dimer concentrations of large intestine patients in blood hypercolktive state. Chemotherapy does not influence the plasma D-dimer concentrations of patients with colorectal cancer.