| 引用本文: | 胡猛慎,洪志玲,黄剑英,李玲玲.非水电位滴定法测定氢溴酸西酞普兰原料药含量的改进[J].中国现代应用药学,2014,31(3):323-325. |
| HU Mengshen,HONG Zhiling,HUANG Jianying,LI Lingling.Optimization of Determination Method of Citalopram Hydrobromide by Non-aqueous Potentiometric Titration[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(3):323-325. |
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| 摘要: |
| 目的 建立革除汞盐的非水电位滴定法测定氢溴酸西酞普兰原料药的含量。方法 采用以冰醋酸-醋酐(1∶5)为溶剂的高氯酸电位滴定法测定氢溴酸西酞普兰原料药的含量。结果 成功革除醋酸汞，所得实验结果与原方法的测定结果基本一致。结论 建立的方法革除了汞盐试剂，滴定突越明显，方法简便、准确，适于氢溴酸西酞普兰原料药的含量测定。 |
| 关键词: 非水电位滴定 革除汞盐 氢溴酸西酞普兰 |
| DOI： |
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| 基金项目:厦门市科技平台(3502Z20121035) |
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| Optimization of Determination Method of Citalopram Hydrobromide by Non-aqueous Potentiometric Titration |
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HU Mengshen, HONG Zhiling, HUANG Jianying, LI Lingling
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Xiamen Institute for Drug Control, Xiamen 361012, China
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| Abstract: |
| OBJECTIVE To establish a determination method of citalopram hydrobromide by non-aqueous potentiometric titration without using mercurate. METHODS Non-aqueous potentiometric titration was used for assay. Citalopram hydrobromide was dissolved in glacial acetic acid-acetic anhydride(1∶5) instead of mercuric salt. RESULTS The results of the improved method were same with that of the original methods. CONCLUSION The improved method discards mercuric salt and obtain an abrupt change of the titration cruve. It is simple and accurate for the determination of citalopram hydrobromide. |
| Key words: non-aqueous potentiometric titration discard mercurate citalopram hydrobromide |
