| 引用本文: | 张乐,王慧静,刘喆,叶霜,王会儒,陆敏华,陆国红.上海市系统性红斑狼疮患者的治疗依从性及经济负担状况分析[J].中国现代应用药学,2018,35(12):1881-1885. |
| ZHANG Le,WANG Huijing,LIU Zhe,YE Shuang,WANG Huiru,LU Minhua,LU Guohong.Research on Treatment Adherence and Economy Burden in Patients with Systemic Lupus Erythematosus in Shanghai[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(12):1881-1885. |
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| 上海市系统性红斑狼疮患者的治疗依从性及经济负担状况分析 |
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张乐1, 王慧静2, 刘喆2, 叶霜2, 王会儒3, 陆敏华4, 陆国红1
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1.上海交通大学医学院附属仁济医院南院药剂科, 上海 200001;2.上海交通大学医学院附属仁济医院南院风湿免疫科, 上海 201112;3.上海交通大学体育系, 上海 200240;4.上海交通大学医学院附属仁济医院风湿科, 上海 200001
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| 摘要: |
| 目的 调查上海市系统性红斑狼疮（systemic lupus erythematosus，SLE）患者的治疗依从性与经济负担的现状，分析影响患者用药和治疗依从性的相关因素。方法 研究纳入于上海交通大学附属仁济医院南院风湿免疫科门诊就诊的SLE患者，进行问卷调查。内容包括患者个人情况、治疗依从性以及经济负担情况，采用风湿病治疗依从性问卷（CQR）和基于访谈的自我报告调查综合评价患者治疗依从性，最后用逐步回归模型进行相关性分析。结果 2017年1-2月，121例就诊于门诊的SLE患者中依从患者为59例（48.7%），直接医疗支出为每年33 899元；多因素回归分析显示SLE的治疗依从性主要与用药提醒工具、可选择性药物、工作强度有关。结论 上海市SLE患者的治疗依从性差，经济负担重。亟需采取有效干预措施提高SLE患者治疗依从性（如有效的提醒工具），改善健康状态，以及减轻经济负担。 |
| 关键词: 系统性红斑狼疮 依从性 经济负担 影响因素 |
| DOI：10.13748/j.cnki.issn1007-7693.2018.12.026 |
| 分类号:R956 |
| 基金项目:国家重点研发计划（2016YFC0903900）；国家自然科学基金项目（71804109）；上海市卫生和计划生育委员会科研课题-青年项目（20174Y0040）；上海市临床药学创新研究项目（2016-YY-01）；上海交通大学医学院附属仁济医院南院国自然培育项目（2017PYQA08） |
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| Research on Treatment Adherence and Economy Burden in Patients with Systemic Lupus Erythematosus in Shanghai |
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ZHANG Le1, WANG Huijing2, LIU Zhe2, YE Shuang2, WANG Huiru3, LU Minhua4, LU Guohong1
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1.South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Pharmacy, Shanghai 201112, China;2.South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Rheumatology, Shanghai 201112, China;3.Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China;4.Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China
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| Abstract: |
| OBJECTIVE To determine treatment adherence and economy burden in patients with systemic lupus erythematosus(SLE) in Shanghai, analyze detailed medication problems and factors associated with treatment adherence in patients with SLE. METHODS Patients with confirmed diagnoses of SLE, visiting the outpatient clinic of the South Campus of Ren Ji Hospital, were recruited and required to complete a series of questionnaires. Data were collected on demographics, treatment adherence and economy burden. Adherence was comprehensively assessed using both the Compliance Questionnaire for Rheumatology(CQR) and interview-based self-reports. A backwards-stepwise multivariate regression analysis was used to identify factors associated with adherence. RESULTS From January to February of 2017, fifty-nine SLE patients(48.7%) were adherent among 121 SLE patients visiting the outpatient clinic. And their annual direct medical costs were 33 899 yuan. According to the result of multivariate regression analysis, treatment adherence of SLE patients was greatly associated with reminder tools, use of alternative medicines and physical strength. CONCLUSION Treatment adherence of patients with SLE in Shanghai are not good and their economy burden are heavy. This indicates it is particularly necessary to improve their healthy condition by taking effective measures to improve treatment adherence(such as using effective reminder tools) and reduce the economy burden in patients with SLE. |
| Key words: systemic lupus erythematosus adherence economy burden influence factors |
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