酮咯酸氨丁三醇注射液药物利用评价标准的建立及应用

Establishment and Application of Drug Use Evaluation Criteria for Ketorolac Tromethamine Injection

关键词:  酮咯酸氨丁三醇注射液  药物利用评价  双硫仑  合理用药

Key words:  ketorolac tromethamine injection  drug use evaluation  disulfiram  rational drug use

摘要:

目的 建立酮咯酸氨丁三醇注射液的药物利用评价标准，并评价其临床用药情况。方法 以药物说明书为基础，参照相关规范和专家共识，建立酮咯酸氨丁三醇注射液药物利用评价标准，采用回顾性研究方法，对亳州市人民医院2019年1月—12月200例使用酮咯酸氨丁三醇注射液的病例进行合理性评价。结果 用药指征符合率为83.5%，用法用量正确率为45.5%，疗程合理率为75.5%，联合用药合理率为55.5%。结论 笔者所在医院酮咯酸氨丁三醇注射液使用合格率较低，主要问题表现在用法用量不适宜，超疗程用药。应特别注意酮咯酸氨丁三醇注射液辅料中含有乙醇，避免发生双硫仑样反应，确保患者用药的安全性。

Abstract:

OBJECTIVE To establish drug use evaluation criteria for ketorolac tromethamine injection, and evaluate its clinical medication. METHODS Based on ketorolac tromethamine injection instruction, referring to related specifications and literatures, drug use evaluation criteria for ketorolac tromethamine injection was established. The utilization of ketorolac tromethamine injection in 200 inpatients of People's Hospital of Bozhou during January 2019-December 2019 was evaluated in retrospective study. RESULTS The coincidence rate of medication indication was 83.5%, the rate of accuracy dosage and accuracy administration was 45.5%, the rate of rational duration of treatment was 75.5%, the rate of rational combined drug was 55.5%. CONCLUSION The qualified rate of ketorolac tromethamine injection in the hospital where the author is located is low. The main problems are inappropriate usage and dosage, and over-treatment medication. Special attention should be paid to the ethanol contained in ketorolac tromethamine injection excipients, to avoid disulfiram-like reactions and ensure the safety of medications for patients.