款冬花不同提取物对豚鼠离体回肠收缩作用的研究

Study the Effects of Different Extracts of Tussilago Farara L. on the Contraction of Isolated Ileum of Guinea Pig

关键词:  款冬花  豚鼠离体回肠  组胺

Key words:  Tussilago Farara L  isolated guinea pig ileum  histamine

摘要:

目的 研究比较款冬花各个不同提取物对豚鼠离体回肠收缩的作用。方法 通过石油醚、乙酸乙酯、CO2超临界萃取等方法制备款冬花多个提取物，将离体豚鼠回肠悬吊于克-亨试液中，观察给药后豚鼠回肠的收缩作用，计算豚鼠回肠收缩幅度抑制率。结果 款冬花各个不同提取物均能降低组胺引起的豚鼠离体回肠收缩幅度。结论 款冬花各个提取物能明显抑制豚鼠回肠收缩运动。

Abstract:

OBJECTIVE To investigate and compare the effect of different extracts of Tussilago farara L. on the contraction of isolated ileum of guinea pig. METHODS By the method of petroleum, acetoacetate and supercritical CO2 , the Tussilago Farara L. was extracted Isolated ileum of guinea pig was put in K-H solution. The contraction extent of isolated ileum was observed. Inhibition ratio of the contraction extent was calculated. RESULTS Different extracts of Tussilago Farara L. decreased the contraction extent of isolated ileum of guinea pig cased by histamine. CONCLUSION The extracts of Tussilago Farara L. significantly inhibited the contraction of isolated ileum of guinea pig .